Abstract
During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine.
Highlights
Fructus psoraleae (补骨脂), a traditional Chinese medical herb, is the dried and mature fruit of Psoralea corylifolia Linn., which is an annual herb of Leguminosae (Figures 1(a)–1(c))
The salt-processed fructus psoraleae could be used as a traditional Chinese medicine in the clinic
A recent study has shown that all the tested compounds in Psoralea corylifolia were absorbed into the blood plasma of rats rapidly, almost evenly distributed in the brain parenchyma, and the overall trend in the brain was basically similar to the results of plasma concentration time
Summary
Fructus psoraleae (补骨脂), a traditional Chinese medical herb, is the dried and mature fruit of Psoralea corylifolia Linn., which is an annual herb of Leguminosae (Figures 1(a)–1(c)). In terms of the ratio of total brain to plasma, isoprene flavonoids were easier to enter the brain than coumarin [3] Another pharmacokinetic report showed that rats taking oral administration and intraperitoneal injection with 20 mg/kg bavachalcone were detected with maximum plasma concentrations of 165 and 740 μg/L, with a drug half-life of 1 and 1.25 h, respectively [4]. Modern pharmacological studies showed that bavachin, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone (Figure 1(d)) had various pharmacological actions and could improve aging-related diseases. We will review the effects and mechanisms of these five psoralea prenylflavonoids on ameliorating aging-related diseases, such as aginginduced chronic low-grade inflammation, cardiovascular dysfunction, diabetes, and obesity, and improving neurodegenerative diseases and osteoporosis
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