Abstract
The variety of wound types has resulted in a wide range of wound dressings, with new products frequently being introduced to target different aspects of the wound healing process. The ideal wound dressing should achieve rapid healing at a reasonable cost, with minimal inconvenience to the patient. Microcurrent dressing, a novel wound dressing with inherent electric activity, can generate low-level microcurrents at the device-wound contact surface in the presence of moisture and can provide an advanced wound healing solution for managing wounds. This article offers a review of the effects and mechanisms of the microcurrent dressing on the healing of skin wounds.
Highlights
Skin, the natural protective barrier for the body, plays an important part in defense against foreign bodies and pathogens, helps retain water and electrolytes, and maintains homeostasis
The results suggested that a low-intensity direct current promoted migration to the negative pole of human dermal fibroblasts
Microcurrent stimulation for accelerating wound healing has been studied for several decades and various types of electric stimulation (ES) devices have been applied in clinical practice, many questions remain about the underlying mechanisms and the intensity and time at which stimulation should be applied to achieve the best effect
Summary
The natural protective barrier for the body, plays an important part in defense against foreign bodies and pathogens, helps retain water and electrolytes, and maintains homeostasis. Mechanisms of accelerated wound healing by ES The exogenous application of microcurrent stimulation can direct cell migration and proliferation, stimulate angiogenesis, reduce the inflammatory response and improve wound healing. Using mutant mice whose PI3K was genetically knocked down, the important function of PI3K in modulating the electric field-induced directional cell migration was proven [55] This characteristic abated electrotactic migration in wound healing in cell and tissue cultures. VEGF was assessed and showed significant expression in the treatment group (66%) and the non-treatment group (38%), compared with 24% in normal skin at the 14th day These data indicate the promising effect of microcurrent for enhancing the release of VEGF and promote wound healing. Other wound healing mechanisms related to ion channels of Ca2+ and Na+ have been proposed but are not well known
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