Effects and Components of Herb Pair Huanglian-Banxia on Diabetic Gastroparesis by Network Pharmacology.

Guoqiang Liang,Fei Wang,Lurong Zhang,Guorong Jiang,Yang Zong,Xuanyi Chen,Min Hui Li

doi:10.1155/2021/8257937

Abstract

Diabetic gastroparesis (DGP) is a serious and chronic complication of long-standing diabetes mellitus, which brings a heavy burden to individuals and society. Traditional Chinese medicine (TCM) is considered a complementary and alternative therapy for DGP patients. Huanglian (Coptidis Rhizoma, HL) and Banxia (Pinelliae Rhizoma, BX) combined as herb pair have been frequently used in TCM prescriptions, which can effectively treat DGP in China. In this article, a practical application of TCM network pharmacological approach was used for the research on herb pair HL-BX in the treatment of DGP. Firstly, twenty-seven potential active components of HL-BX were screened from the TCMSP database, and their potential targets were also retrieved. Then, the compound-target network and PPI network were constructed from predicted common targets, and several key targets were found based on the degree of the network. Next, GO and KEGG enrichment analyses were conducted to obtain several significantly enriched terms. Finally, the experimental verification was made. The results demonstrated that network pharmacological approach was a powerful means for identifying bioactive ingredients and mechanisms of action for TCM. Network pharmacology provided an effective strategy for TCM modern research.

Highlights

Diabetic gastroparesis (DGP) is a serious and chronic complication of diabetes characterized with the disorder of gastric motility and delayed gastric emptying in the absence of mechanical obstruction [1]
A practical application of traditional Chinese medicine (TCM) network pharmacological approach was used for the research on herb pair HL-BX in the treatment of DGP, and the results demonstrated that this approach was an effective strategy for TCM modern research
A practical application of TCM network pharmacological approach was used for the research on herb pair HLBX

Summary

Introduction

Diabetic gastroparesis (DGP) is a serious and chronic complication of diabetes characterized with the disorder of gastric motility and delayed gastric emptying in the absence of mechanical obstruction [1]. The treatment of DGP is aimed at controlling high-level blood glucose and improving gastrointestinal function. It was reported that some chemical drugs, such as domperidone and metoclopramide, improved some symptoms of gastroparesis. These therapeutic drugs have shown limited efficacy but fail to stop or reverse disease progression. Adverse effects further restricted the clinical treatment of DGP [1, 3,4,5]. As a complicated disease [6], DGP may require complex therapeutic approaches such as traditional Chinese medicine (TCM)

Methods

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Discussion

Conclusion