Effects after multiple administration of alcohol on some biochemical parameters in liver and brain in spontaneously hypertensive rats (SHR)

Abstract

Event Abstract Back to Event Effects after multiple administration of alcohol on some biochemical parameters in liver and brain in spontaneously hypertensive rats (SHR) Rumyana Simeonova1, Vessela Vitcheva1* and Mitka Mitcheva1 1 Medical University-Sofia, Departement of Pharmacology, Pharmacotherapy and Toxicology, Bulgaria Introduction. Spontaneously hypertensive rats (SHR) are a genetic model of essential hypertension in human. They are used from many laboratories to characterize some aspects of this pathology, including an influence of some toxic compounds, including alcohol. The aim of the following study was to investigate the effects of multiple alcohol administration on some biochemical brain and hepatic parameters in SHRs, compared to normotensive Wistar-Kyoto rats (WKY). Methods. The parameters: malondialdehyde (MDA), reduced glutathione (GSH) and neuronal nitric oxide synthase (nNOS) were determined in livers and brains from both strains spectrometrically. For the experiment male SHR (strain Okamoto-Aoki, n=12) and WKY (n=12), were used. The animals of each strain were divided into 2 groups: control group and group treated with alcohol (3g/ kg, p.o., 14 days). Results: GSH level was lower in the liver (29%) and in the brain (35%) of SHR, compared to the NTRs, and ethanol administration decreased it in both strains in investigated organs. MDA level was increased in SHR significantly in liver by 38% and in brain by 27% and ethanol administration enhance this parameter in both strains, in both organs, but more pronounced in NTR. nNOS activity was significantly increased in SHR by 31%, compared to NTR and alcohol didn’t affect this parameter in SHR. Conclusions. The difference in the effect of ethanol between the strains might be due to the changed reactivity and pathophysiological characteristics of the hypertensive model. Keywords: alcohol, Ethanol, Malondialdehyde, Glutathione, nNOS, hypertensive models Conference: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010, Thessaloniki, Greece, 1 Oct - 5 Oct, 2010. Presentation Type: Poster Topic: Xenobiotic toxicity Citation: Simeonova R, Vitcheva V and Mitcheva M (2010). Effects after multiple administration of alcohol on some biochemical parameters in liver and brain in spontaneously hypertensive rats (SHR). Front. Pharmacol. Conference Abstract: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010. doi: 10.3389/conf.fphar.2010.60.00197 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Oct 2010; Published Online: 04 Nov 2010. * Correspondence: Dr. Vessela Vitcheva, Medical University-Sofia, Departement of Pharmacology, Pharmacotherapy and Toxicology, Sofia, Bulgaria, vesselavitcheva@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Rumyana Simeonova Vessela Vitcheva Mitka Mitcheva Google Rumyana Simeonova Vessela Vitcheva Mitka Mitcheva Google Scholar Rumyana Simeonova Vessela Vitcheva Mitka Mitcheva PubMed Rumyana Simeonova Vessela Vitcheva Mitka Mitcheva Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.