Abstract
Acne vulgaris (AV) is the most common skin disease, including in Indonesia. This research aims to determine the effectivity of preovulation phase autologous serum application in patients with moderate-severe AV. This research was conducted in Makassar, South Sulawesi. Thirteen patient samples with moderate-severe AV who have met the inclusion criteria were taken from Dr. Wahidin Sudirohusodo General Hospital, Public Senior High School, and Medical Faculty of Hasanuddin University Laboratory. The method used is clinical trial. The examination was done by observing the clinical manifestations, sebum level using 815 sebumeter, and estradiol level examination. All patiens were given the same autologous serum treatment which is applied once a day every night and followed-up on day 21 and day 42. The data were processed using paired t test and Fisher’s exact test. The result showed that there were improvements in clinical manifestation and decreased sebum level after autologous serum application (p < 0.05) on day 21 compared to day 1, on day 42 compared to day 21, and day 42 compared to day 1. Preovulation estradiol level were higher than the estradiol level on menstruation or in lutheal phase (p < 0.05). There were no significant relationship between routine activity, familial history, peanuts, chocolate, spicy and oily food consumption, wearing cosmetics, stress, and squeezing pimples (trauma) with number of acne lesion and sebum level (p < 0.05).
Highlights
Acne vulgaris (AV) is the most common skin disease, including in Indonesia
We found that there was a significant sebum level difference in moderate-severe AV patients after autologous serum application which is significantly lower on day 21 compared to day 1 (p < 0.05), sebum level day 42 compared to day 21 (p < 0.05), and sebum level day 42 compared to day 1 (p < 0.05) (Table 1)
We found that there’s a significant clinical manifestation difference after autologous serum application which is significantly lower on day 21 compared to day 1 (p < 0.05) (Figure 1, 2, and 3), sebum level day 42 compared to day 21 (p < 0.05), and sebum level day 42 compared to day 1 (p < 0.05) (Table 2)
Summary
Acne vulgaris (AV) is the most common skin disease, including in Indonesia. [1, 2] It is a chronic disease of the pilosebaceous unit characterized by comedones, papules, pustules, nodules, and scarring. AV is generally a multifactorial disease characterized by follicular hyperkeratinization, increased sebaceous glands activities, hypercolonisation by Propionibacterium acnes (P. acnes), and inflammation. Androgen hormones increases sebum production and follicular keratosis which is Nurhayati Edison et al.: Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients the key etiology of AV. Androgen hormones stimulate sebaceous glands (sebum) growth and differentiation. All external factors such as stress, smoking, alcohol and food, are interconnected to each other. All external factors such as stress, smoking, alcohol and food, are interconnected to each other. [1, 7, 8]
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