Abstract
Black cumin seeds are known to have beneficial contents as antibacterial. This study aimed to determine the effectiveness of black cumin seed extract (Nigella sativa) on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa. The method used was the disc diffusion method. The ethanol extract of black cumin seeds gain by maceration method and was made into various concentration (5, 7.5, 10, 12.5, and 15)%. For positive control, ciprofloxacin disc were used and negative control used distilled water. The research model used was in vitro experimental research. The results showed that ethanol extract of black cumin seeds have antibacterial activity against Klebsiella pneumoniae with inhibition zone diameters (4.5, 6.7, 10.1, 11, 12.8) mm, Pseudomonas aeruginosa with inhibition zone diameters (7.5, 12, 12.6, 13.4, 15.6) mm, positive controls respectively (24.3 and 20.7) mm and negative controls (0). It can be concluded that black cumin seed extract has an inhibiting effect on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa.
Highlights
Black cumin seeds are known to have beneficial contents as antibacterial
The or respiratory infection that occurs in antibacterial effect of black cumin seeds is health facilities is a health problem that we caused by the content of often encounter in the scope of work of thymohydroquinone, dithymoquinone, medical personnel in the world
Patients who are hospitalized in the antibacterial activity between types of hospital usually have weak immunity so black cumin seeds obtained in Ethiopia and that are getting infection
Summary
The or respiratory infection that occurs in antibacterial effect of black cumin seeds is health facilities is a health problem that we caused by the content of often encounter in the scope of work of thymohydroquinone, dithymoquinone, medical personnel in the world. Triterpene, saponins, thymol, and of nosocomial infections in hospitals are others which denature proteins in the caused due to the use of medical devices bacterial cell wall and damage the bacterial such as ventilators, catheters, use of cell cytoplasm (Sultana et al, 2015; Silvani intravenous lines, or postoperative NS., 2018; Tacakkoli et al, 2017). Patients who are hospitalized in the antibacterial activity between types of hospital usually have weak immunity so black cumin seeds obtained in Ethiopia and that are getting infection
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