Abstract
BackgroundOral mucositis is one of the most emerging and debilitating complications of chemotherapy during the treatment period, which strongly affects the nutritional status and physical and mental condition of these patients. Zinc increased protein synthesis and improved cell membrane stability so passible effective in prevent and treat oral mucositis and promote oral health. Therefore, this study aimed to evaluate the effect of zinc chloride mouthwash on the prevention, incidence, and severity of oral mucositis in cancer patients undergoing chemotherapy.MethodsThe present study was a randomized control trial study. 96 patients with a cancer diagnosis selected from one oncology clinic in the west of Iran. Then they assigned randomly to the zinc chloride group and placebo group. The patients in each group should rinse their mouths every 8 h two times and each time 2 min with 7.5 ml from mouthwash. The severity of mucositis and weight loss examined blindly at the baseline and 3-week follow-up.ResultsThe incidence and severity of oral mucositis between groups were significant higher at the end of the second (p < 0.002) and third (p < 0.001) week. The mucositis severity decreased well during the third weeks in the zinc chloride group. The difference in the weight loss was significant higher between the zinc chloride and the placebo group (p < 0.01).ConclusionZinc chloride mouthwash was effective in preventing and reducing the severity of oral mucositis and improving weight in patients undergoing chemotherapy.Trial registration We can therefore recommend more studies examine the effects zinc chloride as preventive care at the beginning of chemotherapy to improve oral health and subsequently preventing weight loss in these patients.
Highlights
Oral mucositis is one of the most emerging and debilitating complications of chemotherapy during the treatment period, which strongly affects the nutritional status and physical and mental condition of these patients
Sample characteristics The average age of patients participating in this study was 46.21 ± 2.42 years in the zinc chloride group and 46.22 ± 2.33 years in the placebo
Oral mucositis severity 106 patients with cancer were present in the oncology clinic, 10 of whom had not the inclusion criteria, so 96 patients arrived to the study) 48 patients in each group)
Summary
Oral mucositis is one of the most emerging and debilitating complications of chemotherapy during the treatment period, which strongly affects the nutritional status and physical and mental condition of these patients. Mucositis appear from the fourth day of chemotherapy in 40 to 80% of patients undergoing chemotherapy that usually lasts 7 to 14 days after chemotherapy and causes a lot of pain and discomfort in these patients [10,11,12]. Because these patients experience persistent and excruciating pain in the oral cavity when eating and even drinking fluids and talking, which severely affects their nutritional status, physical condition [5, 10], their mental health and quality of life [2, 5, 10]. Despite the high incidence of oral mucositis in patients undergoing chemotherapy, there is no available definitive treatment for mucositis, and only supportive cures were used to reduce pain associated with mucositis [13]
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