Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population-A Community Based Multicenter Randomized Controlled Trial.

Raghuram Nagarathna,Purnima Datey,Saurabh Kumar,Akshay Anand,Hongasandra Ramarao Nagendra,Suchitra S Patil,Ishwara N Acharya,Ramesh H Latha,Amit Kumar Singh

doi:10.3390/medicines8070037

Abstract

Background: Dyslipidemia poses a high risk for cardiovascular disease and stroke in Type 2 diabetes (T2DM). There are no studies on the impact of a validated integrated yoga lifestyle protocol on lipid profiles in a high-risk diabetes population. Methods: Here, we report the results of lipid profile values of 11,254 (yoga 5932 and control 5322) adults (20–70 years) of both genders with high risk (≥60 on Indian diabetes risk score) for diabetes from a nationwide rural and urban community-based two group (yoga and conventional management) cluster randomized controlled trial. The yoga group practiced a validated integrated yoga lifestyle protocol (DYP) in nine day camps followed by daily one-hour practice. Biochemical profiling included glycated hemoglobin and lipid profiles before and after three months. Results: There was a significant difference between groups (p < 0.001 ANCOVA) with improved serum total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein in the yoga group compared to the control group. Further, the regulatory effect of yoga was noted with a significant decrease or increase in those with high or low values of lipids, respectively, with marginal or no change in those within the normal range. Conclusion: Yoga lifestyle improves and regulates (lowered if high, increased if low) the blood lipid levels in both genders of prediabetic and diabetic individuals in both rural and urban Indian communities.

Highlights

IntroductionStudies suggest that Indian and migrant Asian Indians tend to show increased triglycerides and decreased HDL serum levels than western residents [5]
We randomly identified the group as an intervention group, i.e., 2 out of 4 villages and 1 or 2 out of 2 or 4 census enumeration blocks (CEBs) were identified in the selected ward, while the other was assigned as the waitlisted control group
In the first phase of pan-India screening from seven zones (Figure S1), data on Indian Diabetes Risk Score (IDRS) and known diabetes were available on 162,330 individuals from the randomized urban (52%) and rural (48%) clusters

Summary

Introduction

Studies suggest that Indian and migrant Asian Indians tend to show increased triglycerides and decreased HDL serum levels than western residents [5]. There are no studies on the impact of a validated integrated yoga lifestyle protocol on lipid profiles in a high-risk diabetes population. Results: There was a significant difference between groups (p < 0.001 ANCOVA) with improved serum total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein in the yoga group compared to the control group. The regulatory effect of yoga was noted with a significant decrease or increase in those with high or low values of lipids, respectively, with marginal or no change in those within the normal range. Conclusion: Yoga lifestyle improves and regulates (lowered if high, increased if low) the blood lipid levels in both genders of prediabetic and diabetic individuals in both rural and urban Indian communities

Methods

Results

Discussion

Conclusion