Effectiveness of using gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU: a systematic review

Abstract

Objective To systematically evaluate the effectiveness of using gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU. Methods The randomized controlled trials (RCTs) on the application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU were collected through the databases such as the China National Knowledge Infrastructure(CNKI), China Scientific Journal Database by VIP (VIP) and Wanfang Database. The quality of studies was critically appraised and data were extracted by two reviewers independently. Meta -analysis was conducted for the included studies. Results Eleven RCTs involving 1 337 patients were included. Meta-analysis showed that the application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU could reduce ventilator-associated pneumonia (VAP) incidence rate[RR=0.54, 95%CI(0.44-0.65),P 0.05]. Conclusions The application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU is safe and effective. Key words: Chlorhexidine; Nursing care; Respiration, artificial; Meta-analysis