Effectiveness of TruScreen for detecting CIN2+ in women with ThinPrep cytologic test results indicating atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions.

Abstract

Objective: To evaluate the effectiveness of TruScreen (TS) for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in women with abnormal ThinPrep cytologic test (TCT) results. Methods: 466 women with atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) were enrolled and underwent TS, colposcopyand biopsy examination. Results: Compared with thehigh-risk human papillomavirus(hrHPV) test for CIN2+, significantly higher specificity of TS, combined TS and hrHPV (69.6and75.0vs 36.8% in ASCUS;59.0and69.9vs 30.1% in LSIL), significantly higher positive predictive value of combined TS and hrHPV were observed (32.7vs 24.6% in ASCUS;47.9vs 35.6% in LSIL). Conclusion: TS combined with hrHPV showed better performance in diagnosing CIN2+ in ASCUS/LSIL.