EFFECTIVENESS OF TREATMENT OF COMBINED PATHOLOGY OF DIABETES MELLITUS AND MULTIDRUG-RESISTANCE TUBERCULOSIS

Abstract

Objective: The objective of the study is a comprehensive retrospective assessment of the prevalence, features, course of treatment of diabetes mellitus and multidrug-resistant tuberculosis. Design and method: Our study is based on an analysis of statistical data obtained from a retrospective study of 762 case histories and cases of MDR-TB in the register of tuberculosis patients in different regions of Ukraine for 2016-2020. Results: Depending on the type of TB case in our patients, we found that in both groups of the study the recurrence of TB prevailed – 49 cases (55.7%) against TB 39 cases (44.3%) of people in the main group; 363 cases (53.9%) against 311 (46.1%) in the control group (p <0.05). The rate of successful treatment in gr.2 is probably higher than in gr. 1 (64.7% vs. 61.4%; (p <0.05)). However, a more significant probable difference is characterized by the treatment rate, which in the main group is 27.3% versus 40.3% in the control group (almost 2 times; p <0.05). The rate of ineffective treatment, which in patients with comorbidity was 27.3% (almost every third patient) against 17.6% in group 2 is also important for scientists and practitioners. Conclusions: There is a clear tendency to increase the combined pathology and chemoresistance in the structure of the incidence of tuberculosis, the proportion of recurrences of tuberculosis in the presence of diabetes mellitus. The pulmonary tuberculosis developed significantly more often in middle-aged patients with type 2 diabetes mellitus with moderate and severe states, the subcompensated form, with a complicated course.