Abstract
THE disadvantage of xenogeneic (or heterologous) anti-lymphocyte serum (ALS) is the development of hyper-sensitivity, anaphylaxis and the production of antibodies to the foreign protein1,2. We wanted to determine whether an effective allogeneic antiserum could be raised which would avoid some of these disadvantages. The rabbit was chosen because it is a good producer of circulating antibody and has been used3–7 to raise a potent ALS against another species. Because of the disappointing results of Balner and Dersjandt8 with allogeneic ALS in rhesus monkeys, we immunized the same rabbits with mouse lymphoid cells simultaneously so that some assessment could be made of the immunosuppressant activity of the resultant ALS if the allogeneic component turned out to be weak or inactive.
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