Abstract
This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L. acidophilus fermentation via increases in its indicator molecule.
Highlights
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers that are innocuous to normal nonatopic individuals [1]
We report that newly formulated herbal medicine Korea Institute of Oriental Medicine (KIOM)-MA possesses strong antiatopic activity and KIOM-MA128, fermented form by L. acidophilus, exerts more potent inhibitory effect on AD
Six maker compounds of KIOMMA and KIOM-MA128 liquiritin, nodakenin, icariin, glycyrrhizin
Summary
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers that are innocuous to normal nonatopic individuals [1]. Several studies have suggested that atopic dermatitis is the cutaneous manifestation of a systemic disorder that gives rise to asthma, food allergy, and allergic rhinitis [3, 4]. These conditions are all characterized by elevated serum IgE levels and peripheral eosinophilia [5]. There has been increased interest in the use of traditional herbal medicine to develop new therapeutic agents without a steroid for AD treatment [10]. Recent studies have suggested that fermentation of herbal extracts may affect the therapeutic potential due to their increased absorptive effect [17]. We report that newly formulated herbal medicine KIOM-MA possesses strong antiatopic activity and KIOM-MA128, fermented form by L. acidophilus, exerts more potent inhibitory effect on AD
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