Abstract
The article presents the results of experiment on testing a prolonged form of the Iverlong drug against gastrointestinal nematodes in sheep. The work was carried out on 30 lambs. The lambs of the first group were subcutaneously injected with the Iverlong preparation at a dose of 1 ml/50 kg of live weight (in 1 ml of 50 mg of Ivermectin plus PLGA prolongator), the lambs of the second group were treated with the same preparation, but at a dose of 0.5 ml/50 kg of live weight. The lambs of the third group served as a control, which were subcutaneously injected with the well-known Ivomek drug in the recommended dose (1 ml/50 kg of live weight). The effectiveness from the prolonged form of Iverlong in 2 doses against nematodes of the gastrointestinal tract was taken into account by means of coprological studies before drug administration and every 15 days for three months. According to the results of coprological studies, it was found that the Iverlong drug in a dose of 1ml/50 kg of the animal’s live weight showed a high prolonged anthelmintic effect and for 60 days protected animals from infection by nematodes of the gastrointestinal tract.
Highlights
An important problem in veterinary medicine remains the prevention and treatment of parasitic diseases in farm animals, which cause significant economic damage to animal breeding
The lambs of the first group were subcutaneously injected with the Iverlong drug at a dose of 1 ml/50 kg of live weight; the lambs of the second group were treated with the same preparation, but in a dose of 0.5 ml/50 kg of live weight
The lambs of the third group served as a control, which were subcutaneously injected with the well-known Ivomek drug in the recommended dose of 1ml/50 kg of live weight
Summary
An important problem in veterinary medicine remains the prevention and treatment of parasitic diseases in farm animals, which cause significant economic damage to animal breeding. The composition of the pharmaceutical preparation affects the absorption of the IVM and its systemic availability. After the first approved preparation (IVM) (propylene glycol/glycerin, 60:40) used at a dose of 200 mg/kg of live weight was put into practice, various pharmaceutical modifications were analyzed to increase its activity [1]. The processes of absorption, distribution, metabolism and excretion (pharmacokinetic phase) directly affect the concentration of the drug achieved at the site of action, and the effective therapeutic effect. In addition to other factors, the route of administration can significantly affect the pharmacokinetic behavior of anthelmintic molecules and change their effectiveness. Oral administration increases the effectiveness of the drug against nematodes located in the gastrointestinal tract [1]
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