Effectiveness of the haemonetics MCS cell separator in the collection of apheresis platelets

Abstract

Platelet (PLT) transfusions play an important role in patients with thrombocytopenia or severely impaired platelet function. Platelet concentrates are prepared from whole-blood donations or by plateletpheresis. In recent years, different instruments have been developed to perform plateletpheresis. We evaluated an apheresis instrument, the Haemonetics MCS® + with regard to PLT yield, collection efficiency (CE), and collection rate (CR) in a retrospective, randomized study in 526 donors. In this system, we used leukoreduction filters post collection to obtain leukoreduced products. The Haemonetics MCS® + cell separator efficiently collected apheresis platelets with median PLT yields of 3.7 × 1011, mean CE of 66.69 ± 13.73% and mean CR of 0.063 ± 0.013 × 1011/min. The median blood volume processed was 3290 (2420–4370) ml, and the median volume of acid citrate dextrose-A (ACD-A) used in collections on the device was 385 (196–517) ml. Also, this device allowed the collection of white blood cell (WBC) reduced plateletpheresis with mean 0.07 ± 0.15 × 106 WBC content. No serious donor or recipient reactions occurred.