Effectiveness of the combination therapy with lisinopril, ivabradine and multivitamin supplementation in anthracycline-induced severe cardiotoxicity

Abstract

Introduction: Left ventricular (LV) dysfunction mimicking congestive heart failure represents the most dramatic feature of anthracycline-induced cardiotoxicity (AIC) [1–4]. Over the last decade, a growing interest arose about less cardiotoxic compounds and more valuable cardioprotective strategies [5]. Doxorubicin and epirubicin are potent cancer-fighting medications belonging to the group of asantineoplastics, in particular to the family of anthracyclines, habitually used in breast cancer patients.