Abstract
BackgroundThe aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS).MethodsTreatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014–2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen).ResultsWe included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL ≥ 50 copies/ml) changed due to virological failure.ConclusionsEVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads.
Highlights
The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegra‐ vir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + darunavir mg (DRV)) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS)
Patients were selected from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS), which has been described in detail elsewhere [12, 13]
We included all treatment-experienced patients who started treatment with EVG/COB/TFV/FTC + DRV from January 2014 to November 2018 and who had more than 24 weeks of follow-up
Summary
The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegra‐ vir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Treatment adherence is crucial for the effectiveness of antiretroviral therapy (ART) among HIV-infected patients. Suárez‐García et al AIDS Res Ther (2020) 17:45 once-daily dosing [1]; this is a frequent situation among patients with drug-resistant HIV. The association of one of those fixed-dose combinations with darunavir 800 mg (DRV) would allow a once-daily, two-pill regimen that includes three classes of antiretroviral drugs and could be used to treat selected patients with drug-resistant HIV.
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