Abstract
BackgroundIn this study, we reviewed our experiences and previous studies on surgery for recurrent cholangiocarcinoma (CCA). MethodsWe analyzed outcomes of 117 patients with recurrent CCA between 2000 and 2015. Twenty-one patients (17.9%) underwent surgical resection for recurrence, and the remaining 96 patients (82.1%) did not undergo resection. We evaluated patients’ clinicopathological features and prognoses between the two groups. ResultsPatients who underwent surgery were significantly associated with better overall survival after recurrence (HR = 0.22, P < 0.0001). In patients with recurrent CCA, surgery for recurrence was an independent better prognostic factor after recurrence (HR = 0.27, P = 0.0002), and in patients who underwent surgery for recurrent CCA, the presence of lymph node metastasis of primary cancer was an independent worse prognostic factor (HR = 9.45, P = 0.04). ConclusionsSurgery for recurrent CCA may provide good survival impact in selected patients. Patients with lymph node metastasis of primary CCA should not undergo surgery for recurrent CCA.
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