Effectiveness of skin protectors and calendula officinalis for prevention and treatment of radiodermatitis: an integrative review.

Valdete Oliveira Santos,Rodrigo Nogueira Da Silva,Fabiana Verdan Simões,Rafael Celestino Da Silva

doi:10.1590/0034-7167-2019-0815

Valdete Oliveira Santos, Rodrigo Nogueira Da Silva + Show 2 more

Open Access

https://doi.org/10.1590/0034-7167-2019-0815

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Abstract

to analyze the effectiveness of skin protectors and Calendula officinalis for prevention and treatment of radiodermatitis. an integrative review conducted at CINAHL, Cochrane Library, Embase, MEDLINE/PubMed, IBECS, LILACS, and Web of Science. The final sample consisted of five studies, four clinical studies and one preclinical. Critical appreciation and narrative synthesis of the findings were carried out. the Cavilon™ skin protector was more effective than Sorbolene (cream with 10% glycerin) and less effective than Mometasone Furoate cream. Calendula officinalis was more effective than Trolamine and essential fatty acids and less effective than Ching Wan Hung® for prevention and treatment of radiodermatitis. data confirm the potential of Calendula officinalis for prevention and treatment of radiodermatitis and point to promising results regarding skin protector use; however, there is a need for further testing as to the effectiveness of such products.

Highlights

Cancer is a health condition in which cells in a certain part of the body, due to some mutation in the genome, grow and reproduce uncontrollably
This study aims to analyze the effectiveness of skin protectors spray and Calendula officinalis for prevention and treatment of radiodermatitis
Thirty-nine study participants hairless mice): [1] Ching Wan Hung® (CWH), a Chinese herbal ointwere randomly allocated to 3 groups: [1] 3MTM CavilonTM No Sting ment that is sold as a lotion for burns, and [2] Calendula officinalis

Summary

Introduction

Cancer is a health condition in which cells in a certain part of the body, due to some mutation in the genome, grow and reproduce uncontrollably. In Brazil alone, in 2018, there were more than 630 thousand new cases of malignant neoplasms[2]. Radiotherapy is a safe and highly effective treatment against cancer, either for healing or for palliation, which works by emitting ionizing radiation in a region of the body, in order to destroy and prevent tumor cells from growing[3]. Despite being a very precise technique, normal tissues that are exposed to radiation can suffer toxic effects. Such effects can be short term, during treatment or up to three months after it ends, or long term, after three months of ending treatment[3]

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