Abstract
(1) Purpose: The employment of platelet-rich fibrin (PRF) in the extracted teeth socket has been shown to aid tissue healing. It also minimizes detrimental consequences. The rationale of this systematic review is to observe the possible association between PRF employment and postoperative consequences following mandibular third molar surgery. (2) Materials and Methods: The following databases were explored electronically (till 28 February 2021): PubMed, Cochrane library, Embase, International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov. A manual explore was accomplished on various journals regarding the subject of oral and maxillofacial surgery. The online explore applied the keywords “platelet-rich fibrin or PRF,” and “mandibular third molar.” To review the efficiency of PRF, the accompanying post-operative consequences were collected: pain, swelling, trismus, inter-incisal distance, analgesic consumption, soft tissue healing, bone healing, socket complications, and periodontal parameters. (3) Results: Just 9 full-text studies out of 26 were comprised of review for qualitative analysis. All of the studies were randomized clinical trials (RCTs), with eight split-mouth designs and one parallel design study. Significant outcomes were usually observed for pain, postoperative swelling, mouth opening, periodontal pocket depth, soft tissue healing, and the incidence of alveolar osteitis or dry sockets, but not constantly. The qualitative scrutiny disclosed that the PRF had no considerable outcome in bone healing. (4) Conclusions: Local administration of PRF is a practical way of alleviating pain, trismus, oedema, and enhancing soft tissue healing following mandibular third molar extraction. PRF tends to have no function in bone healing following extraction. More controlled clinical trials and RCTs are necessitating exploring the end results of PRF following mandibular third molar extraction.
Highlights
The frequent surgical intervention carried out by oral and maxillofacial surgeons is the extraction of the mandibular wisdom teeth [ ]
We reviewed this study to appraise Platelet-Rich Fibrin (PRF) e ciency in post-extraction lower third molar socket healing and complications following surgery
PRF is said to permit the gradual discharge of cytokines such as platelet derived growth factor (PDGF), transforming growth factor (TGF), endothelial growth factor (EGF), and vascular endothelial growth factor (VEGF), all of which are key elements for the development of new blood vessels, tissue repair, and cicatrization [, ]
Summary
The frequent surgical intervention carried out by oral and maxillofacial surgeons is the extraction of the mandibular wisdom teeth [ ]. Trismus, swelling, in ammation, and alveolar osteitis (AO) are all potential postoperative consequences of the surgical removal of the mandibular third molar [ ]. ( ), third molar extraction, platelet-rich plasma (PRP) was reported to minimize pain, in ammation, and AO, and enhance the healing process of both the soft and hard tissue [ , ]. In oral and maxillofacial surgeries, PRF has turned into an e ective surgical additive. Post-extraction alveolar ridge restoration, sinus lift operation, alveolar cleft repair, dental implants, surgical dealing of drug-associated jaw osteonecrosis, and management of oroantral communications are several of the possible utilization of PRF in oral surgeries [ ]
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