Abstract
Aim:The current study was conducted to evaluate the effect of platelet-rich fibrin matrix (PRFM) treated with silver nanoparticles (AgNPs) on enhancing the healing of the experimentally induced bone gap in a rabbit model.Materials and Methods:Twenty healthy male local rabbits aged between 6 and 8 months, their weights between 1.5 and 2 kg were used in this study and divided randomly into four equal groups, under general anesthesia (1 cm), bone gap was induced in the tibia bone to create a critical bone defect and leave it without any treatment in the first group (control group). While in the second group the bone gap was filled with PRFM; in the third group, the gap was filled with 0.3 ml AgNPs; and in the fourth group, the gap was filled with PRFM treated with AgNPs.Results:There was no infection at the operation site in all experimental animals, and the radiograph images showed periosteal and endosteal reaction; the gaps were bridged faster in the fourth group as compared with the other groups. The histological examination showed lamellar bone with haversian canal completely filled the fracture gap and contact with old bone in the fourth group as compared to other groups.Conclusion:Using a combination of PRFM and single nucleotide polymorphisms together gave better acceleration in the bone healing process than using each one of them separately.
Highlights
Bone repair is a complex process that involved cellular functions and mineralization followed by remodeling of the defect site to attain the original structure [1]
The current study provided evidence that the olive leaves were a good source for synthesizing stable AgNPs in lesser time
The total amount of AgNPs which produced from 500 g of olive leaves powder was 17.5 g
Summary
Bone repair is a complex process that involved cellular functions and mineralization followed by remodeling of the defect site to attain the original structure [1]. The preparation process of PRF matrix (PRFM) creates a gel-like matrix which is characterized by high levels of non-activated, functional, intact platelets and trapped within a fibrin matrix that releases a relatively constant concentration of growth factors over a period of 7 days [5,6,7]. Nanomaterials had been developed quickly because of their exact characteristics such as size and morphology [9] These properties related to grander specific areas and energies, which normally increased the reactivity of surface than those of the grander particles, leads to greatly changed properties. Due to these features, nanoparticles (NPs) were increasingly used in many products such as energies, medicines, environmental remediation, and biomedical devices [10,11,12]. Nanosilver was evidenced to be a most active material which possesses respectable antibacterial properties against different microorganisms, for example, viruses, bacteria, fungi, and parasite [15]
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