Abstract
Background:Ketamineisalreadyinuseinthenebulisedform,forattenuatingPOST,Dexmedetomidine,ontheotherhandis known to cause sedation and analgesia. The aim of our study was to assess the respective incidence and severity of POST and compare the effectiveness of nebulised dexmedetomidine and nebulised ketamine in reducing or alleviating POSTin adult patients undergoing thyroidectomy under GA. Method:Aprospective,randomized, double-blinded, comparative studywas conducted on a total of 96 patients,further divided into two age and gendermatched groups, in Super Specialty Hospital, GMC Jammu, over a period of 1 year. Patients in the age group of 18-60 years, who were scheduled to undergo elective thyroid surgery under general anaesthesia (GA) with endotracheal intubation, were included in the study. First group received ketamine 50mg (1mL) with saline (4mL) nebulisation and second group received dexmedetomidine 50µg (1mL) with saline (4mL) nebulisation. Results: No signicant difference in the mean age (in years), mean weight, gender ratio and duration of surgery between the two groups. Incidence of POST was 14.58% (7/48) in ketamine and 16.66% (8/48) in dexmedetomidine group, at 2 Hour interval. Severity was moderate for two patients in each group at 2 hour interval. POST persisted for a longer duration in Ketamine group as compared to Dexmedetomidine group. Signicant reduction in the severity of sore throat in both groups at all time points during 24 Hours. Conclusion:NebuliseddexmedetomidinemaybeconsideredasasafealternativetonebulisedketamineforalleviatingPOST
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