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Abstract
Serum samples from children immunized with a meningococcal serogroup B vaccine demonstrated potent serum bactericidal antibody activity against the hypervirulent Neisseria meningitidis serogroup W strain circulating in England. The recent introduction of this vaccine into the United Kingdom national immunization program should also help protect infants against this endemic strain.
Highlights
Invasive meningococcal disease (IMD) has been declining in the United Kingdom since the early 2000s [1]
The ability of the antibodies raised by Bexsero antigens to induce SBA activity against any given meningococcal isolate depends on the presence, level of surface expression, and sequence diversity of the respective antigens
Bexsero strain coverage can be predicted by using the Meningococcal Antigen Typing System, an ELISA which measures the level of antigen expression and antigenic diversity compared with the antigen in the vaccine [9]
Summary
We assessed 1) the NadA and NHBA genotypic status of endemic MenW:cc isolates, and 2) the serum bactericidal antibody (SBA) activity against clinical MenW:cc isolates using serum samples from infants immunized with Bexsero. The Study A total of 73 invasive MenW:cc isolates from England and Wales were received by the Public Health England Meningococcal Reference Unit during July 2010–June 2013. These isolates were queried within the Meningitis Research Foundation Meningococcus Genome Library (http:// pubmlst.org/perl/bigsdb/bigsdb.pl?db = pubmlst_neisseria_mrfgenomes) for nadA and nhba and, where present, their respective allelic and peptide variants. Preimmunization serum samples showed no detectable hSBA titers against any of the 6 isolates (Table)
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