Effectiveness of MAID Therapy against Metastatic Malignant Phyllodes Tumors and Stromal Sarcoma of the Breast

Abstract

Malignant phyllodes tumors and stromalsarcoma are rare malignancies of the breast. The efficacyof systemic chemotherapy against metastatic malignantphyllodes tumors and metastatic stromal sarcoma remainsunknown. Patients and Methods: We retrospectivelyanalyzed 8 patients with metastatic malignantphyllodes tumors or stromal sarcoma, who were treatedwith MAID (mesna, doxorubicin, ifosfamide, dacarbazine)chemotherapy. The MAID therapy was administeredintravenously every 4 weeks as follows: mesna1,500 mg/m2/day, days 1-4; doxorubicin 20 mg/m2/day,days 1-3; dacarbazine 300 mg/m2/day, days 1-3; ifosfamide2,500 mg/m2/day, days 1-3. Results: Althoughcomplete response was not achieved in any of the patients,4 of the 8 patients showed partial response. Themedian time to disease progression was 74 days, andthe overall median survival was 148 days. Grade 3 ormore severe hematological toxicity was encountered inall patients. Conclusion: MAID therapy for metastatic malignantphyllodes tumors and stromal sarcoma was moderatelyeffective in terms of tumor reduction. However,the treatment was associated with severe toxicity.