Abstract
Lacosamide is a novel antiepileptic with neuroprotective properties. The present study examined the effectiveness of Lacosamide on cognitive functioning, psychiatric symptoms, and resilience in patients of refractory partial epilepsy. This prospective study was conducted at Sheikh Zayed Hospital;Rahim Yar Khan, Nishter Hospital, Multan; and Bahawal Victoria Hospital, Bahawalpur, Pakistan, from November 2017 till May 2018.Thirty-six patients of refractory partial onset epilepsy and 36 healthy individuals particiated in the study.The participants completed brief psychiatric rating scale and brief resilience scale, while their informants completed everyday cognition questionnaire in baseline (pre-treatment) and post-Lacosamide treatment testing sessions. Patients with epilepsy had cognitive deficits, psychiatric symptoms, and lesser resilience in contrast with healthy individuals. Lacosamide treatment improved everyday cognition, reduced psychiatric symptoms and improved resilience in patients with epilepsy. Lacosamide is efficacious in the treatment of everyday cognitive impairment, psychiatric symptoms and resilience in patients with epilepsy.
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