Effectiveness of Inositol on clinical features, endocrine and metabolic profiles in infertile patients with polycystic ovary syndrome

Abstract

Objectives: This study aimed to assess the impact of Inositol on the clinical characteristics, endocrine and metabolic profiles of infertile PCOS patients from Vietnam.
 Methods: From June 2018 to June 2022, a clinical trial was undertaken at the Center for Reproductive Endocrinology and Infertility on infertile women aged 18 to 40 with PCOS. The clinical, endocrine, and metabolic features of these individuals were assessed before and after 3 months of treatment with 2g of Inositol per day. Natural pregnancy rates, adverse effects, and tolerance of Inositol have also been recorded.
 Results: After three months of Inositol treatment, 18.2% of patients with oligomenorrhea experienced regular menstruation. Inositol therapy dramatically lowered hips circumference and Testosterone levels, but had no effect on other clinical characteristics, endocrine profiles, or metabolic profiles. In the overweight and obese group, weight, BMI, waist and hip circumferences decreased dramatically while regular menstrual cycles were improving in non overweight/ obse group. 9.4% of patients reported experiencing side effects; despite this, 100% of women tolerated Inositol and maintained treatment. 18.9% of them attained pregnancy, which resulted in 17% live births.
 Conclusion: Inositol appears to increase menstrual cycle regularity and decrease Testosterone levels; resulting in a clinical pregnancy rate of 18.9% and a live birth rate of 17.0%. Inositol appears to be more beneficial in improving weight, BMI, waist and híp circumference in the obese and overweight population.