Abstract
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Highlights
As the effectiveness of beta-agonists for treating asthma attacks has been established, numerous other supportive treatments for asthma attacks have been investigated, such as systemic glucocorticoids and magnesium
We identified six studies using double-blinded, randomized control trial designs that evaluated inhaled furosemide in conjunction with standard treatments in patients experiencing asthma attacks [1,2,3,4,5,6] (Figure 1); a total of patients received inhaled furosemide and patients received a placebo (Tables 1 and 2)
Integrating the standardized mean difference in each study, a random effects model showed that inhaled furosemide had a significant positive effect on asthma attacks (Z = 2.70; 95% confidence interval, 0.14 to 0.85; P = 0.007) with a negligible heterogeneity (I2 = 16.82) (Figure 2 and Table 3)
Summary
As the effectiveness of beta-agonists for treating asthma attacks has been established, numerous other supportive treatments for asthma attacks have been investigated, such as systemic glucocorticoids and magnesium. We identified six studies using double-blinded, randomized control trial designs that evaluated inhaled furosemide in conjunction with standard treatments in patients experiencing asthma attacks [1,2,3,4,5,6] (Figure 1); a total of patients received inhaled furosemide and patients received a placebo (Tables 1 and 2). Integrating the standardized mean difference in each study, a random effects model showed that inhaled furosemide had a significant positive effect on asthma attacks (Z = 2.70; 95% confidence interval, 0.14 to 0.85; P = 0.007) with a negligible heterogeneity (I2 = 16.82) (Figure 2 and Table 3).
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