Abstract
Background 
 Cancer is the uncontrolled growth and spread of cells. Chemotherapy is a potentially life-saving medication for people with malignancies that act by targeting cancer and non-cancer rapid dividing cells. Nurses are the prominent persons exposed to these drugs during the preparation and administration of antineoplastic agents.
 Objectives 
 To find out the effectiveness of educational program on pediatric nurses’ knowledge about chemotherapy administration.
 Methods
 Quasi-experimental research design (pre-posttest) has been utilized in this study. Tool of data collection was built; the program was constructed. To obtain validity (15), experts were selected from different specialties. The pilot study was done on six nurses in the pediatric department in Hiwa cancer hospital within the first two weeks of January 2018, and reliability of the tool was done. Sixty-nine nurses were selected purposively. 
 Data were collected in three phases; before the educational program, the data was collected as a pre-test, an educational program which was consist of 12 sessions was applied, and the last phase collected data in the same questionnaire after the educational program as post-test. Data was analyzed by using the Statistical Package of Social sciences (V-21).
 Results
 The result of the study has shown significant differences in mean scores between pre- and post-program application, which indicates the effectiveness of the applied program to the nurses at a P-value (<0.001). 
 Conclusion
 According to the study’s findings, the educational program was effective, and nurses’ level of knowledge has risen after they participated in educational sessions.
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