Abstract
BackgroundAnorexia nervosa (AN) is a debilitating psychiatric disorder associated with a wide array of negative health complications and psychiatric comorbidity. Existing evidence for AN treatment in adults is weak, and no empirically supported treatment has been reliably established. The primary objective of this study is to gain knowledge about the effectiveness of enhanced cognitive behavioral therapy (CBT-E) for anorexia nervosa delivered in a public hospital setting. Baseline predictors of treatment outcome and dropout are studied. Furthermore, there will be collected blood and stool samples for a general biobank to be able to initiate research on possible pathophysiological mechanisms underlying AN.MethodsThe study will assess the potency of outpatient CBT-E in a sample of patients suffering from AN (age >16) admitted to the Section for Eating Disorders at the Department for Psychosomatic Medicine, Haukeland University Hospital in Bergen, Norway. The study has a longitudinal design with five main assessment time points: before treatment, at 3 months, at the end of treatment, at 20 weeks, and at 12 months follow-up including biobank samples. A control group without an eating disorder will also be recruited.DiscussionTreatment research in a public hospital setting is important for gaining knowledge about the transportability of treatments evaluated in research clinics into ordinary clinical practice. Furthermore, biological material from the thoroughly described patient cohort will serve as a basis for further research on the pathophysiological mechanisms in AN.Trial registrationClinicalTrials.gov Identifier: NCT02745067. Registered 14 April 2016.
Highlights
Anorexia nervosa (AN) is a debilitating psychiatric disorder associated with a wide array of negative health complications and psychiatric comorbidity
Evaluation of outpatient cognitive behavioral therapy (CBT)-E as a standard treatment for adult AN patients in a public hospital As discussed above, the existing evidence for AN treatment is weak and no empirically supported treatment has been reliably established for adults with AN [12, 14, 15]
The cognitive behavioral therapy (CBT-E) model is based on the assumption that common cognitive mechanisms, such as overevaluation of body shape and weight, underlie all eating disorders [17]
Summary
Anorexia nervosa (AN) is a debilitating psychiatric disorder associated with a wide array of negative health complications and psychiatric comorbidity. General overview Anorexia nervosa (AN) is a debilitating psychiatric disorder characterized by abnormal eating behaviors, severe weight loss, intense fear of gaining weight or becoming fat (despite being underweight), and having a disturbed body image [1]. AN is associated with a wide array of negative health complications that cause suffering. This condition is associated with a poor prognosis, including high rates. A substantial proportion of AN patients develop severe and enduring AN [11]. The adverse effects of AN combined with the high risk of severe and enduring AN indicate a substantial need for effective treatment options
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