Abstract
BackgroundPolyethylene glycol solution (PEG) is widely used for bowel preparation prior to colonoscopies. However, patients often exhibited adverse events as nausea, vomit and distention due to its uncomfortable tastes and potential side affects. This study aimed to evaluate the effectiveness and safety of concomitant use of green tea (GT) with PEG in bowel preparation prior to colonoscopy.MethodsThis was a prospective, randomized controlled study. It was conducted at an outpatient setting of colorectal surgery in a tertiary hospital. Patients aged 18 through 80 who were scheduled to undergo colonoscopy between August 2015 and February 2016 were randomly assigned into two groups, admitting either 2 L-PEG solutions with 1 L GT liquids or 2 L-PEG solutions only for bowel preparation. Admitted doses of PEG solutions, taste evaluation, adverse reactions (nausea and vomiting, distention and abdominal pain) were investigated by questionnaires. The bowel cleanliness of each patient was evaluated according to the Aronchick indicators.ResultsA total of 116 patients were enrolled in this study (PEG+GT 59, PEG 57). Full compliances were achieved in 93.2% patients of group PEG+GT and 59.6% of group PEG (p < 0.001). Mean Aronchick scale between two groups were 2.0 ± 0.9 versus 2.2 ± 0.7 respectively (PEG+GT vs PEG, p = 0.296). Rates of adverse events as nausea and vomiting, abdominal pain in bowel preparation were significantly different between two groups (55.9% vs 77.2%, p = 0.015 and 13.6% vs 33.3%, p = 0.012). Patients in group PEG+GT who have probabilities to receive repeating colonoscopy had a higher willingness to accept PEG+GT again for bowel preparation, compared with PEG group (94.9% vs 57.9%, p < 0.001).ConclusionsConcomitant use of green tea and polyethylene glycol may effectively reduce incidence of adverse events, increase compliances, with comparable bowel cleanliness in bowel preparation.Trial registrationThis trial was retrospectively registered on Feb 1st, 2019 (ChiCTR1900021178).
Highlights
Polyethylene glycol solution (PEG) is widely used for bowel preparation prior to colonoscopies
Based on the investigation and the comparison of a large number of clinical studies, the ‘consensus of bowel preparation in colonoscopy’ published by the American Society of Gastrointestinal Endoscopy (ASGE), the American Society of Colon and Rectal surgeons (ASCRS) and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) in 2006 [6], suggested that polyethylene glycol electrolyte solution (PEG) is a fast and effective method for bowel cleansing with improved tolerance, which is considered superior to the high-dose laxatives and mannitol that require patient fasting
During the process of ingestion of PEG solution, the majority of the patients develop adverse reactions, such as nausea, vomiting, abdominal distention and pain, due to its bitter taste. This results in poor tolerance from patients which lead to incomplete administration of the polyethylene glycol electrolyte solution and in turn influence the efficacy of bowel preparation
Summary
Polyethylene glycol solution (PEG) is widely used for bowel preparation prior to colonoscopies. Based on the investigation and the comparison of a large number of clinical studies, the ‘consensus of bowel preparation in colonoscopy’ published by the American Society of Gastrointestinal Endoscopy (ASGE), the American Society of Colon and Rectal surgeons (ASCRS) and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) in 2006 [6], suggested that polyethylene glycol electrolyte solution (PEG) is a fast and effective method for bowel cleansing with improved tolerance, which is considered superior to the high-dose laxatives and mannitol that require patient fasting. During the process of ingestion of PEG solution, the majority of the patients develop adverse reactions, such as nausea, vomiting, abdominal distention and pain, due to its bitter taste. This results in poor tolerance from patients which lead to incomplete administration of the polyethylene glycol electrolyte solution and in turn influence the efficacy of bowel preparation
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