Effectiveness of complex treatment of cats for chronic kidney disease

Abstract

Treatment of cats with chronic kidney disease should be aimed at slowing the progression of the disease, which contributes to the preservation of residual kidney function, the elimination of clinical signs of CKD, and the quality of life of sick animals. During the II stages of chronic kidney disease in cats, hyporexia (60 %), polyuria and polydipsia (50 %), anemia of mucous membranes (60 %), impaired coordination of movements (30 %), vomiting and ulcerative stomatitis (40 %), an increase in serum levels of creatinine and urea (P > 0.001), the level of symmetric dimethylarginine (P < 0.001), the concentration of cystatin C (P > 0.001), a decrease in the rate of glomerular filtration, the level of total calcium (P < 0.001), an increase in the level of inorganic Phosphorus and Potassium. Arterial hypertension was established in 8 cats; the risk was moderate (148 ± 4.7 / 98 ± 3.8 mmHg). Changes in the physical properties and chemical composition of urine have been established. The application of complex treatment of cats with II stages of chronic kidney disease for 14 days contributed to the restoration of appetite, increased motor activity, the absence of anemia of visible mucous membranes and vomiting, and a decrease in the level of polyuria and polydipsia was established. Hematological indicators improved, the content of symmetric dimethylarginine in blood serum (Р < 0.001), Cystatin C (Р < 0.001), the level of total calcium (Р < 0.001) normalized, azotemia decreased (Р < 0.001), the rate of glomerular filtration increased (Р < 0.001), the level of inorganic Phosphorus and Potassium (Р < 0.001). An increase (Р < 0.001) in the relative density of urine and a decrease in the content of protein and creatinine were noted in the urine. For arterial hypertension in cats with chronic kidney disease, life-long therapy is indicated, which is adjusted according to the needs and condition of the animal.