Abstract
Local control rates for T1b-T2 glottic carcinoma are not satisfactory. The purpose of this study was to evaluate the outcomes of patients with T1-T2 glottic carcinoma treated with radiotherapy and to evaluate the effects of chemoradiotherapy for T1b and T2 disease. At Hiroshima City Asa Citizens Hospital, 49 patients with early glottic carcinoma underwent radiotherapy from July 2006 to December 2015. Of these, 46 patients were enrolled and evaluated. The median age was 70.5 years (range, 39-88 years), and 43 patients (93.5%) were men and 3 patients (6.5%) were women. All patients presented with squamous cell carcinoma. Twenty-eight (60.1%) had T1a, 6 (13%) had T1b and 12 (26.1%) had T2 disease. In T1 and T2 patients, 2 Gy/fraction was used and the total prescribed dose ranged from 60 to 66 Gy and from 60 to 70 Gy, respectively. The patients with T1b and T2 were administered chemotherapy. The patients with T1 disease had a 5-year local control rate of 90.9%, while patients with T2 disease had a local control rate of 80.0%. The patients with T1a disease had a 5-year local control rate of 88.9%, while patients with T1b disease had a local control rate of 100%. Chemoradiotherapy for patients with T1b-T2 glottic carcinoma is feasible and may contribute to improved local control of patients with T1b disease.
Highlights
Glottic cancer is the most common laryngeal cancer
Patients with T1-T2N0 squamous cell carcinoma of the glottic larynx may be treated with transoral laser excision, open partial laryngectomy, or radiotherapy [1]
The purpose of this study was to evaluate the outcomes of patients with T1-T2 glottic carcinoma treated with radiotherapy and to evaluate the effects of chemoradiotherapy for T1b and T2 disease
Summary
Glottic cancer is the most common laryngeal cancer. Patients with T1-T2N0 squamous cell carcinoma of the glottic larynx may be treated with transoral laser excision, open partial laryngectomy, or radiotherapy [1]. Many studies showing the effectiveness of radiotherapy for glottic carcinoma have been reported. In T1 disease, T1b glottic carcinoma tends to have a lower local control rate of approximately 80% [2-4]. These results are not satisfactory, especially for T2 cases. If local recurrence is observed in patients who were initially treated with radiotherapy, the patients will undergo salvage surgery. Several studies have reported that chemoradiation was safe and effective for T2 glottic carcinoma [7-10]. There are few published studies that evaluated the effects of chemoradiation for T1b disease
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