Effectiveness of biomimetic nanohydroxyapatite on remineralisation of carious lesion: A systematic review

Abstract

Dental caries is a prevalent infectious disease of the dental hard tissue. Simple non-invasive remineralization of dental caries may be sufficient to stop the progression of incipient carious lesions. Research question was formulated based on the PICO strategy. A comprehensive electronic literature search was conducted, independently by two reviewers. Based on the specified inclusion and exclusion criteria, the selected articles were subjected to quality assessment and the risk of bias evaluation was done.The objective of this study was to conduct a systematic review of the literature on effectiveness of nanohydroxyapatite on remineralization of caries in comparison with other conventional remineralizing agents.A search was performed in electronic database (i.e. PubMed, Cochrane and google scholar) using search terms alone and in combination by means of PubMed search builder from January 2010 to January 2023. Studies were selected if they met the following criteria: randomized clinical trials comparing nanohydroxyapatite and other remineralizing agents for caries remineralization. Nanohydroxyapatite has comparable efficacy on remineralization of dental caries. Biomimetic hydroxyapatite-containing, fluoride-free oral care products are effective in remineralization of dental caries, especially in children. Additional long-term studies employing standardized protocols are necessary to draw definitive findings about the effect of hydroxyapatite on remineralization of dental caries. Nano-hydroxyapatite is a biomimetic and have a remineralizing effect on early carious lesions.