Effectiveness of basal bolus insulin (BBI) administration versus other insulin regimen administration methods for hospitalized adult, non-critical care patients with hyperglycemia: a systematic review protocol

Abstract

Review question/objective What type of insulin regimen (basal bolus insulin or other insulin regimens) for hospitalized adult non-critical care patients is more effective in achieving lower overall mean blood glucose and fewer episodes of hypoglycemia? Inclusion criteria Types of participants This review will consider studies that include acute care, hospitalized, non-critical care patients, 18 years or older, females and males, with all types of conditions or diseases including surgical procedures, and at all stages of severity that required hyperglycemia management. Types of interventions This review will include studies that evaluated the effectiveness of basal bolus insulin protocol for hospitalized adult, non-critical care patients, which includes a combination of long and rapid acting insulin regimens as compared to insulin regimens using rapid acting or regular insulin alone for the treatment of hyperglycemia. Types of outcomes This review will consider studies that included the following outcome measures: •mean daily blood glucose levels; •overall mean blood glucose achieved during hospitalization; and •episodes of hypoglycemia.