Abstract
Background: In recent decades, improvement in sensory and motor function after spinal cord injury(SCI) is a major treatment goal. Stem cell therapy has become a promising treatment strategy in theregeneration of central nervous system injuries.Methods: We assessed the effectiveness of autologous Schwann cell (SC) and bone marrow-derivedmesenchymal stem cell (MSC) for individuals with SCI in promoting sensory recovery. Five patientswith a mean ± SD age of 38.80 ± 5.84 years were enrolled in the study. The follow-up course was12 months.Results: We found sensory changes in two patients assessed by the American Spinal InjuryAssociation’s (ASIA’s) impairment scale. Systemic complications were not observed during thecourse of the study.Conclusion: There were no adverse finding after cell transplantation. Also we observed improvementin sensory score in two patients. It seems that the use of this combination of cell therapy may beeffective; but large group studies with control group are required to clarify the effect of either cells.
Highlights
Spinal cord injury (SCI) is a highly damaging clinical condition with permanent and economic disabilities for patients and communities
We aimed to investigate the effectiveness of co-transplantation of autologous bone marrow mesenchymal stem cell (MSC) and Schwann cell (SC) in promoting sensory recovery in patients with spinal cord injury (SCI)
The second patient had improvement at the sensory level after the injection. He had type A ASIA Impairment Scale (AIS) before injection and his sensory score based on ASIA criteria was 29 for the right side and 29 for the left side
Summary
Spinal cord injury (SCI) is a highly damaging clinical condition with permanent and economic disabilities for patients and communities. A promising treatment strategy for injuries to the central nervous system is stem cell therapy. Improvement in sensory and motor function after spinal cord injury (SCI) is a major treatment goal. Stem cell therapy has become a promising treatment strategy in the regeneration of central nervous system injuries. Methods: We assessed the effectiveness of autologous Schwann cell (SC) and bone marrow-derived mesenchymal stem cell (MSC) for individuals with SCI in promoting sensory recovery. We observed improvement in sensory score in two patients It seems that the use of this combination of cell therapy may be effective; but large group studies with control group are required to clarify the effect of either cells.
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