Effectiveness of autologous growth factor concentrates combined with topical minoxidil in patients of androgenic alopecia

Abstract

Abstract Background: Concentrated growth factor (CGF) is a form of platelet concentrate. CGF contains abundant autologous growth factors that can promote cell proliferation, migration, osteogenic differentiation, and angiogenic properties in wound healing and bone regeneration. Recent studies revealed that CGF injection in hairless scalp could enhance hair density and optimize hair growth in androgenic alopecia (AGA) patients. Objective: The objective of this study was to study the effectiveness of autologous growth factor concentrate (GFC) combined with topical minoxidil in patients of AGA. Materials and Methods: A prospective nonrandomized interventional study with before and after comparison was carried out among 22 patients diagnosed with AGA. They were treated with deep intradermal injections of GFC in scalp. Four injections were administered 4 weeks apart, and patients were followed for 16 weeks. Treatment outcomes were assessed by taking photographs, using Global Aesthetic Improvement Scale (GAIS), and by performing a hair pull test after 16 weeks of therapy and compared to baseline. Incidence of adverse events was recorded. Patient’s self-satisfaction was assessed using a survey-based questionnaire at the end of the study. Results: Global macroscopic photographs showed a significant improvement in hair growth post-GFC therapy in all 22 patients. GAIS suggested that GFC treatments were effective in treating AGA, and the majority of patients were satisfied with their improvement. Hair pull test was negative in 100% of patients 4 months posttherapy. Therapy was found to be well tolerated with high patient satisfaction (100%). In addition, treatments resulted in a faster rate of hair growth and a decrease in greasy and unpleasant sensation of hair. Conclusion: GFC was found to have a promising role in the management of AGA in both males and females.