Abstract
830 patients receiving 1 oral contraceptive tablet/day (10 mg noreth ynodrel plus .15 mg ethinyl estradiol 3-methyl ether) from Cycle Days 5 through 24 were studied for effects upon fertility menstrual phenomena and health. The mean cycle length was 28.6 days. Breakthrough bleeding occurred in only 2% of the cycles. 46% of the cycles showed no change in menstrual flow 48% showed a decrease and 6% showed an increase. Side reactions of nausea headache dizziness vomiting gastralgia and malaise declined to low levels after the 1st cycle. 200 pelvic examinations revealed a normal size involuted postpartum uteri even after 30 or more cycles of treatment an inconsistent change in the amount of cervical erosion and no pathological changes of the adnexae or vagina. Little difference was noted between the efficacy of 10 and 5 mg dosages. Practically 100% contraception occurred when the regimen wa s practiced faithfully. When 1-5 tablets were missed 5 pregnancies/10 0 woman-years occurred and when 6-19 tablets were missed 11 pregnancies/100 woman-years were noted. 32-50% of the patients who withdrew from the regimen did so because of reactions or lack of interes t. No impairment of fertility was noted in either short- or long-term users.
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