Abstract

PurposeThe objective of this study was to examine the impact of an academic detailing programme in primary care in Norway on the prescribing rate of diclofenac, naproxen and non-steroidal anti-inflammatory drugs (NSAIDs) in total.MethodsAn academic detailing programme was delivered to general practitioners (GPs) in two Norwegian cities. The key message was to avoid diclofenac and COX-2 inhibitors and to use naproxen as the NSAID of choice. We analysed prescription data for 12 months before and after the programme to estimate its impact, using interrupted time series to control for underlying trends, and using the rest of Norway as a comparator. The primary outcome was change in the proportion of the population filling a prescription for diclofenac; secondary outcomes were change in naproxen prescribing and change in total NSAID prescribing.ResultsControlling for baseline trends, and relative to changes in the rest of Norway, there was a statistically significant reduction in the prescribing rate of diclofenac in both cities (− 18% and − 16%, respectively) immediately after the intervention. The impact of the programme on prescribing of diclofenac was maintained by the end of the 12 month follow-up period. An increase in the prescribing of naproxen was observed in both cities. The programme had no impact on the overall rate of prescribing of NSAIDs.ConclusionAcademic detailing was effective in changing the choice of prescribed NSAID amongst Norwegian GPs. Academic detailing is potentially an important method for providing GPs with independent, evidence-based updates on pharmacotherapy to improve prescribing.

Highlights

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most widely prescribed medicines; they have potentially severe side effects and are one of the major reasons for hospital admissions attributed to adverse effects

  • The European Medicines Agency published new safety advice for diclofenac in June 2013 [7], an advice that was reiterated by the Norwegian Medicines Agency (NOMA) [8]

  • The objective of this study was to evaluate if the academic detailing programme in Norwegian primary care had an impact on the prescribing rate of diclofenac, naproxen and NSAIDs in total

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Summary

Introduction

Non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most widely prescribed medicines; they have potentially severe side effects and are one of the major reasons for hospital admissions attributed to adverse effects [1, 2]. NOMA and other Norwegian health authorities informed prescribers of the new guidelines for diclofenac, using direct communication, adverts in the Journal of The Norwegian Medical Association, warnings in the online version of the Norwegian Pharmaceutical Product Compendium (Felleskatalogen) and automatic reminders (Bpop-ups^) in the general practitioners’ prescribing tools. Those interventions had some impact, and from 2013 to 2014, the prescribing rate of diclofenac in Norway was reduced by 11.0% [9]

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