Abstract
BackgroundTo evaluate the clinical effectiveness of a topical sialogogue spray (malic acid, 1%) in the treatment of xerostomia in patients with chronic Graft versus Host Disease (cGVHD).Material and MethodsThis study was designed as a randomized double-blind clinical study. Twenty-eight patients with cGVHD suffering from xerostomia were divided into 2 groups: the first group (14 patients) received a topical sialagogue spray containing malic acid 1% (SalivAktive®) whereas the second group (14 patients) received a placebo. Both groups received treatment for 2 weeks. Dry Mouth Questionnaire (DMQ) scores and unstimulated salivary flows rate were collected before and after treatment.ResultsDMQ scores increased significantly from 1.3 ± 0.4 to 3.5 ± 0.4 points (p <0.05) after two weeks of treatment with malic acid, whereas in the control group DMQ scores increased from 1.2 ± 0.7 points to 1.4 ± 0.6 (p >0.05). The unstimulated salivary flow rate in patients treated with malic acid increased significantly from 0.15 ± 0.06 mL/min to 0.24± 0.08 mL/min, while that of the patients treated with placebo went from 0.16 ± 0.07 mL/min to 0.17 ± 0.09 mL/min (p >0.05).ConclusionsMalic acid 1% spray can be considered effective in the treatment of GVHD induced xerostomia. Key words:Xerostomia, malic acid, transplantation.
Highlights
Graft versus host disease (GVHD) is one of the most frequent and serious complications of hematopoietic stem cell transplantation
The chronic form is characterized by the involvement of several organs, including the oral cavity, which could represent the primary site of chronic GVHD [1,2,3]
-Dry Mouth Questionnaire (DMQ) scores DMQ scores increased significantly from 1.3 ± 0.4 to 3.5 ± 0.4 points (p0.05). -Unstimulated salivary flow rate After two weeks of treatment, the unstimulated salivary flow rate increased significantly from 0.15 ± 0.06 mL/ min to 0.24± 0.08 mL/min whereas that of the patients treated with placebo went from 0.16 ± 0.07 mL/min to 0.17 ± 0.09 mL/min (p>0.05)
Summary
Journal section: Medically compromised patients in Dentistry Publication Types: Research doi:10.4317/medoral.22699 http://dx.doi.org/doi:10.4317/medoral.22699. Elena Bardellini 1, Francesca Amadori 2, Giulio Conti 3, Federica Veneri 4, Alessandra Majorana 5. Bardellini E, Amadori F, Conti G, Veneri F, Majorana A. Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease. Med Oral Patol Oral Cir Bucal. 2019 Mar 1;24 [2]:e190-4
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