Effectiveness of a Novel Dentifrice Containing Stabilized Chlorine Dioxide, Sarkosyl, and Sodium Fluoride.

Srinivas Rao Mynenivenkatasatya,Esmeralda Garcia-Smith,Jaiprakash Shewale,Howard Wang,James Ratcliff,William Cooley

doi:10.3390/dj8040122

Srinivas Rao Mynenivenkatasatya, Esmeralda Garcia-Smith + Show 4 more

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https://doi.org/10.3390/dj8040122

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Abstract

This in vitro study evaluated the effectiveness of a novel dentifrice containing stabilized chlorine dioxide, sodium lauroyl sarcosinate (sarkosyl), and sodium fluoride in enhancing enamel fluoride uptake, remineralization, pellicle cleaning and inhibiting biofilm regrowth. Remineralization was measured by fluoride uptake and surface microhardness assessment tests. Artificial stains were removed and scored based on pellicle cleaning ratio. Biofilm regrowth was measured by counting colonies on the agar plates. All studies were conducted using bovine teeth specimens. The efficacy of Toothpaste C (CloSYS anticavity toothpaste) was compared with United States Pharmacopoeia Reference Dentifrice, Toothpaste B (discontinued CloSYS anticavity toothpaste formulation) and leading commercial toothpastes. The enamel fluoride uptake and remineralization by Toothpaste C was 96.1% to 303.3% and 38.0% to 102.4% higher than the tested toothpastes, respectively. The mean pellicle cleaning ratio of Toothpaste C was similar to American Dental Association Reference Material. Toothpaste C had a significant reduction in regrowth of the oral polymicrobial biofilm compared to the control. All tested toothpastes contained 0.24% sodium fluoride. Toothpaste C exhibited significantly superior performance towards fluoride uptake and remineralization compared to the tested toothpastes. Therefore, toothpaste ingredients other than sodium fluoride accounted for the enhanced fluoride uptake and remineralization.

Highlights

IntroductionDental caries is one of the most common preventable chronic diseases affecting human beings [1]
Dental caries is one of the most common preventable chronic diseases affecting human beings [1].Aside from proper tooth brushing techniques, the selection of a dentifrice is one of the most crucial components for maintaining a healthy dentition and preventing dental caries [2,3]
Average fluoride concentration (based concentration on numerousmeasured in vitro after enamel fluoride uptake in studies the baseline concentration in the single-sourced bovine enamel utilized as fluoride the test concentrations determined) in the single-sourced bovine enamel utilized as the test substrate substrate is less were than 100 ppm

Summary

Introduction

Dental caries is one of the most common preventable chronic diseases affecting human beings [1]. Aside from proper tooth brushing techniques, the selection of a dentifrice is one of the most crucial components for maintaining a healthy dentition and preventing dental caries [2,3]. Showed that the use of different brands of dentifrices can lead to varying incidences of caries in an animal model, despite the fact that the dentifrices may all contain fluoride [4]. The performance exhibited by a given dentifrice cannot be explained by the fluoride content alone, but rather by the synergistic effect of the different ingredients in a dentifrice formula [5]. Evaluation of the effectiveness of a dentifrice in preventing caries and plaque should be based on several objectives: (a) the ability of

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