Abstract
The relevance of improving treatment methods for patients with dyspepsia is important due to widespread prevalence, negative impact on the quality of life and regularly updated pathogenetic conception of this syndrome. Objective. To evaluate the effectiveness and safety of methylmethionine sulfonium chloride as part of combination therapy in patients with epigastric pain in real clinical practice. Materials and methods. An anonymous, retrospective, non-interventional clinical study of 408 patients with a primary diagnosis of dyspepsia (K30.0) treated with a combination of omeprazole (20 mg) and methylmethionine sulfonium chloride (300 mg) or omeprazole (20 mg) for 30 days for epigastric pain syndrome. Results. In patients receiving combination therapy, epigastric pain was relieved in 80.1% versus 68.3% in patients receiving monotherapy (p=0.007). Adverse effects of therapy in the group of patients receiving vitamin U occurred in 13.1% versus 6.9% in the group of patients receiving omeprazole monotherapy (p=0.03), but this did not affect patient adherence to treatment. Conclusion. The reliable effectiveness of methylmethionine sulfonium chloride as part of combination therapy in patients with dyspepsia in real clinical practice demonstrated.
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