Abstract
Background and objectiveTo systematically evaluate the clinical effects and safety of traditional Chinese medical bath therapy (TCMBT) combined with ultraviolet irradiation in the treatment of psoriasis.MethodsElectronic database retrieval was utilized. The foreign retrieval databases consulted included those of the Cochrane Library, PubMed and EMBASE; the domestic retrieval databases included the Chinese Biomedical Literature Database (Sino-Med), the China National Knowledge Infrastructure (CNKI), VIP and the WangFang Database. Clinical randomized controlled trials were conducted to evaluate the effects of TCMBT combined with ultraviolet irradiation in the treatment of psoriasis; the language of the retrieved articles was Chinese or English. Each database was searched from its inception to August 1, 2015. Two researchers independently collected the data and analyzed the methodology of the documented literature. The researchers conducted a meta-analysis with RevMan 5.2.3 software.ResultsAccording to the available literature, 25 RCTs (randomized controlled trials) of low research quality were conducted. According to the meta-analysis, the total effective rate of TCMBT combined with ultraviolet irradiation was relatively higher than that of ultraviolet irradiation alone. The recurrence rate, incidence of adverse reactions and Psoriasis Area and Severity Index (PASI) for the combined therapy was lower than that of ultraviolet irradiation (P<0.05).ConclusionFor the treatment of psoriasis, the clinical effects and safety of TCMBT combined with ultraviolet irradiation are generally better than those of ultraviolet irradiation alone. However, the original literature was written in Chinese, and the quality of the studies was not high. Thus, it is difficult to confirm the clinical effects and safety of TCMBT combined with ultraviolet irradiation. It is necessary to conduct a scientific, normalized and high-quality RCT with multiple large samples and centers.
Highlights
The skin is the first barrier of the human body, being a kind of heterogeneous organ, covers the whole body with the functions of defense, feeling[1], body temperature regulation, secretion and excretion function[2,3], etc
According to the meta-analysis, the total effective rate of traditional Chinese medical bath therapy (TCMBT) combined with ultraviolet irradiation was relatively higher than that of ultraviolet irradiation alone
For the treatment of psoriasis, the clinical effects and safety of TCMBT combined with ultraviolet irradiation are generally better than those of ultraviolet irradiation alone
Summary
The skin is the first barrier of the human body, being a kind of heterogeneous organ, covers the whole body with the functions of defense, feeling[1], body temperature regulation, secretion and excretion function[2,3], etc. Psoriasis is a chronic relapsing inflammatory skin disease with the joint participation of a variety of immune cells. UVB in narrow-spectrum is one of important means for clinical treatment of psoriasis but its mechanism has not been fully determined It may include effects, such as, the release of induced apoptosis[15], cytokines that has influence on various of cytokines, immunosuppression, the regulation of immunosuppression and endocrine regulation[16,17,18,19], anti-angiogenesis and anti-proliferation, etc. Through the physical effect of medical therapy, hydrotherapy, and thermal therapy, TCMBT was designed to treat psoriasis and maintain health through stimulation of the skin and its main and collateral channels, administration of acupuncture, and transdermal absorption of drugs. To systematically evaluate the clinical effects and safety of traditional Chinese medical bath therapy (TCMBT) combined with ultraviolet irradiation in the treatment of psoriasis
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