Abstract
Objective The aim of this study is to systematically evaluate the clinical efficacy and safety of the traditional Chinese medicine prescription Jade Screen combined with desloratadine in the treatment of chronic urticaria. Methods Two researchers independently conducted literature searches. The extracted data were analyzed using Rev Man 5.2.3 software. The established retrieval time range of the various databases was up to 15 March, 2017. Results Sixteen randomized controlled trials were included in this study. The results of the meta-analysis showed that the total effective rate of using Jade Screen and desloratadine in combination to treat chronic urticaria was higher than that with desloratadine alone (P < 0.00001), while its recurrence rate (P < 0.00001) and symptom score (P = 0.006) were both significantly lower than the latter. The rate of adverse reaction in the combination group was lower than that when orally taking desloratadine alone (P = 0.74), and the serum level of total IgE in the combination group was lower than that when orally taking desloratadine alone (P = 0.82); however, the results of the rate of adverse reaction and the serum level of total IgE were insignificant. Conclusion Using Jade Screen and desloratadine together to treat chronic urticaria gains a better clinical effect than using desloratadine alone.
Highlights
Urticaria is a common disease in dermatology, characterized by transient, localized, edematous wheals of various sizes on skin mucous membranes and accompanied by severe itching
Using a fixed effects model, meta-analysis indicated that the overall response rate of Jade Screen combined with desloratadine for the treatment of chronic urticaria was significantly higher than that of the oral use of desloratadine alone [n = 16, odds ratio (OR) = 2.72, 95% CI (2.13, 3.48), Z = 7.97, P < 0.00001], Figure 4
The fixed effects model revealed that the recurrence rate of Jade Screen combined with desloratadine for the treatment of chronic urticaria was significantly lower than that of the oral use of desloratadine alone [n = 8, OR = 0.16, 95% CI (0.11, 0.25), Z = 8.25, P < 0.00001], Figure 5
Summary
Urticaria is a common disease in dermatology, characterized by transient, localized, edematous wheals of various sizes on skin mucous membranes and accompanied by severe itching. If wheals occur every day or almost every day for more than six weeks, such condition is called chronic urticaria [1]. 0.5%∼1.0% of the world population has chronic urticaria [2]. The conventional treatment method involves the single use or combined use of antihistamine drugs [7]. These drugs can only relieve the symptoms of some patients, and the overall effect is not significant. There is an urgent need to seek new therapeutic strategies [2]
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