Abstract
Effectiveness and Safety of Oral Paricalcitol Therapy on Long-Term Treatment of Normocalcemic Persistent Secondary Hyperparathyroidism in Renal Transplant Patients
Highlights
Secondary hyperparathyroidism (SHPT) is a very frequent complication in renal transplant recipients (RTRs)
The percentage reduction of parathyroid hormone (PTH) levels at follow-up was more than 50% in 18 patients out of 24
Patients in which the reduction of PTH levels at follow-up was less than 50%, when compared with patients who showed a reduction percentage of PTH levels>50%, were characterized before RTx by higher PTH levels (626 ± 719 pg/ml vs. 341 ± 145 pg/ml; P
Summary
Secondary hyperparathyroidism (SHPT) is a very frequent complication in renal transplant recipients (RTRs). It is estimated that in about 30-50% of RTRs at one year after renal transplantation (RTx) serum parathyroid hormone (PTH) levels remain high [1]. Post-transplant persistent SHPT has been associated with a high bone turnover, responsible for bone mass loss and a higher risk of fracture [2,3], and progression of vascular calcification [4]. Persistent SHPT in 10-40% of RTRs is associated with serum calcium levels at the upper normal limits or hypercalcemia, in particular during the first year of post-RTx [1,5]. High serum calcium levels can contribute to a greater risk of calcification of the graft and to a reduced renal function [6], as well as to reduced patient and graft survival [7]. The important consequences of persistent SHPT have persuaded many authors to take into account an earlier treatment of it, which is not done regularly yet [6,7]
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