Effectiveness and Safety of Levothyroxine Tablets Combined with Iodine-131 in the Treatment of Thyroid Cancer

Abstract

Objective To explore the effectiveness of levothyroxine tablets combined with iodine-131 in thyroid cancer patients after radical thyroidectomy and the effect on their serum thyroglobulin (Tg) and thyroglobulin antibody (TgAb) levels. Methods A total of 70 thyroid cancer patients receiving radical thyroidectomy in our hospital from July 2015 to April 2016 were recruited and were assigned via different treatment methods (1 : 1) to receive either levothyroxine tablets (observation group) or levothyroxine tablets plus iodine-131 (control group). Outcome measures included treatment efficiency, 1, 3, and 5-year recurrence and metastasis, serum Tg and TgAb levels, postoperative survival, and adverse reactions. Results The total effective rate of treatment in the control group was significantly higher than that in the observation group (P < 0.05). There was no significant difference in cancer recurrence and metastasis rate between the two groups one year postoperatively (P > 0.05). The rate of cancer recurrence and metastasis in the control group was significantly lower than that in the observation group 3 and 5 years after surgery (P < 0.05). Before treatment, there was no significant difference in serum Tg and TgAb levels between the two groups (P > 0.05). After treatment, serum Tg and TgAb levels decreased in both groups, with lower results in the control group (P < 0.05). There was no significant difference in the 1 and 3-year survival rates between the two groups (P > 0.05). The 5-year survival rate in the control group was significantly higher than that in the observation group (P < 0.05). There was no significant difference in adverse reactions between the two groups (P > 0.05). Conclusion Levothyroxine tablets combined with iodine-131 for thyroid cancer patients undergoing radical thyroidectomy effectively could improve the treatment efficiency, reduce the risk of cancer recurrence and metastasis after surgery, lower the serum Tg and TgAb levels of patients, and prolong the survival of patients, with a high safety profile. Further trials are, however, required prior to clinical promotion.