Abstract
Objective: To evaluate the effectiveness and safety of a novel intra-articular formulation of hyaluronic acid (HA) to treat athletes with articular lesions. Methods: Multicenter, prospective, interventional, observational study analyzing the clinical evolution of athletes who received 2 or 3 intra-articular injections of HA. The study was scheduled in Visit 1 (week 0), Visit 2 (week 1), Visit 3 (week 2), Visit 4 (week 3), and Visit 5 (end of follow up, week 24). The change in Visual Analog Scale (VAS) of pain and in Knee Injury and Osteoarthritis Outcome Score (KOOS) and the rate of return to physical activity were evaluated upon treatment initiation for up to 24 weeks. The incidence of adverse events was recorded throughout the study. Results: Sixty patients were recruited: 28 (46.7%) in the 2-injection group and 32 (53.3%) in the 3-injection group. Mean VAS gradually decreased across the visits, with statistically significant reductions in both groups from Visit 2 to Visit 3 and to Visit 5 (P < 0.0001). Inter-group differences in the change in VAS from Visit 2 to Visit 5 were statistically comparable (P = 0.8271). At Visit 5, the KOOS of all subscales statistically improved in both treatment groups. At the end of follow-up (Visit 5), 75.9% of patients returned to sport in the overall population. Only one patient reported an adverse event. Conclusion: This novel formulation of HA is effective and safe for at least 24 weeks, resulting in a promising treatment option for athletes with articular lesions.
Highlights
Articular lesions are a major source of pain and disability and represent a serious burden for patients and healthcare systems [1]
Such articular lesions can be localized in specific joints that in the long-term tend to progress to degenerative conditions such as osteoarthritis (OA) [4]
Clinical information was collected at baseline and longitudinally over the visits to assess the change in pain and function, the rate and time to return to physical activity, and the incidence of adverse events upon hyaluronic acid (HA) treatment
Summary
This work is licensed under a Creative Commons Attribution 4.0 International License. EFFECTIVENESS AND SAFETY OF INTRA-ARTICULAR HYALURONIC ACID IN ATHLETES WITH ARTICULAR LESIONS: A MULTICENTER, PROSPECTIVE OBSERVATIONAL STUDY Dr Jordi Puigdellívol Grifell, Centre Integral de Medicina Esportiva, Traumatologia i Rehabilitació, Spain Dr Juan Pérez Estévez, Universidad de los Andes, Chile Dr Enrique Herrera Otto, Clinica Sanatorio Aleman, Chile Dr Jordi Marcos, Centre Integral de Medicina Esportiva, Traumatologia i Rehabilitació, Spain Dr Mindaugas Gudelis, F.C. Barcelona, Spain Received: 28 September 2021 Accepted: 25 November 2021 Published: 30 November 2021 KEYWORDS hyaluronic acid, intra-articular injection, articular lesions, pain, athletes.
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