Abstract
ABSTRACTPurposeTo assess effectiveness and durability of Solifenacin (SS) versus tibial nerve stimulation (PTNS) versus combination therapy (PTNS + SS) in women with overactive bladder syndrome (OAB).Materials and Methods105 women with OAB were divided randomly into three groups of 35 patients each. In group A women received SS, in group B women underwent PTNS, in group C women underwent combination of PTNS + SS. Improvements in OAB symptoms were assessed with OABSS questionnaire; patients’ quality of life was assessed with OAB-q SF questionnaire. Evaluation of effectiveness of treatments was performed with PGI-I questionnaire. OABSS and PGI-I were also assessed monthly for ten months.ResultsAll treatments were effective on symptoms. PTNS showed a greater effectiveness than SS, but PTNS + SS was more effective than SS and PTNS. Furthermore, PTNS + SS showed a greater duration of effectiveness than PTNS and SS.ConclusionsCombination of PTNS with SS showed more effectiveness and more durability than PTNS and SS alone.
Highlights
Overactive bladder syndrome (OAB) is a chronic disease characterized by urinary urgency with or without urge incontinence, frequency and nocturia [1] with huge economic burden and detrimental effects on the quality of life of patients [2]
In recent years several studies have shown that a combination of two different anticholinergic or one anticholinergic combined with the β3-adrenoceptor agonist Mirabegron may improve efficacy in the treatment of OAB symptoms while reducing the side ibju | solifenacin versus percutaneous tibial nerve stimulation versus their combination for the treatment of women with overactive bladder syndrome effects [8]
Improvements with statistically significant differences were found in all the items assessed with Overactive Bladder Symptom Score (OABSS) questionnaire in the three groups of patients: day time frequency, night time frequency, urgency and urge incontinence (Table-1)
Summary
Overactive bladder syndrome (OAB) is a chronic disease characterized by urinary urgency with or without urge incontinence, frequency and nocturia [1] with huge economic burden and detrimental effects on the quality of life of patients [2]. In recent years several studies have shown that a combination of two different anticholinergic or one anticholinergic combined with the β3-adrenoceptor agonist Mirabegron may improve efficacy in the treatment of OAB symptoms while reducing the side ibju | solifenacin versus percutaneous tibial nerve stimulation versus their combination for the treatment of women with overactive bladder syndrome effects [8]. The aim of this study was to assess the efficacy and the long term durability of Solifenacin (SS) and percutaneous tibial nerve stimulation (PTNS) administered alone or in combination in the treatment of women with OAB syndrome
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