Abstract
The effect of the gel preparation on the rate of absorption of a vaginally administered insulin which was suspended in a polyacrylic acid aqueous gel base was investigated in the alloxan diabetic rats and rabbits. When insulin (dose 1 IU/kg) was given into the vagina in the gel preparation (0.1%, pH 6.5) to rats and rabbits, the plasma insulin reached a peak, and prominent hypoglycemie effects were observed during the first 30 min, which is indicative of a facilitated rate of vaginal absorption of insulin by the polyacrylic acid aqueous gel base. p]However, the plasma insulin quickly diminished after 1h and plasma levels returned to the initial level after 3 h.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
