Abstract
Abstract In this study we report on a flexible straight forward synthesis toward novel 3,5-diaryl-(1 H )-pyrazin-2-ones. Our synthetic strategy involved an acyclic di-keto derivative as key intermediate. The final pyrazin-2-one ring closure reaction was yield-optimized by using a microwave mediated procedure and ammoniumacetate as nitrogen source. Our method is a suitable alternative to palladium-catalyzed coupling reactions for the 3,5-diaryl decoration of the (1 H )-pyrazin-2-one scaffold. Since the (1 H )-pyrazin-2-ones is present as scaffold in a number of biologically active compounds the reported synthetic platform is a useful approach to generate a set of highly diverse 3,5-diaryl-(1 H )-pyrazin-2-one compounds.
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