Abstract
The role of rehabilitation in managing symptoms of multiple sclerosis (MS) and promoting functional recovery has grown exponentially over the past 12 years. Evidence now supports strength and aerobic training for individuals with mild or moderate disease. An emerging body of evidence suggests that exercise may play a role in the production of brain-derived neurotrophic factor in individuals with MS, and the combination of pharmacological management and rehabilitation may produce better outcomes than one therapeutic intervention alone. Rehabilitation and exercise should be a major focus in the comprehensive management of MS.
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